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JAPAN鈥檚 health ministry found one probable case of the mysterious severe acute hepatitis affecting children in the US, the UK, and 10 other countries, raising concerns that the disease is spreading outside of Europe and the US.聽聽

The infection, likely the first case in Asia, was found in a young child. While an adenovirus was detected in more than 40% of cases globally, the patient in Japan tested negative, according to authorities. The child, whose age wasn鈥檛 disclosed, hasn鈥檛 had a liver transplant, it said.聽聽聽

One child has died and more than a dozen have undergone liver transplants as a result of a mysterious outbreak, the World Health Organization (WHO) said last week. Seventeen children, or about 10% of cases, have required a liver transplant and at least one death has been reported, according to the Geneva-based agency.聽聽

The WHO warned that it鈥檚 鈥渧ery likely that more cases will be detected before the cause can be confirmed and more specific control and prevention measures can be implemented.鈥澛犅

UK health authorities are investigating whether there鈥檚 a potential link between the pandemic and the hepatitis outbreak.聽聽聽

Symptoms include liver inflammation, with markedly high liver enzymes and jaundice, a liver-linked ailment, preceded by abdominal pain, diarrhea and vomiting, said the WHO. Typical causes for viral hepatitis have been excluded. One child died and more than a dozen have undergone liver transplants, the WHO said.聽聽

Japan鈥檚 health ministry alerted local governments and asked to report suspected cases on April 20. It will regularly release the situation of the outbreak in Japan, while working with governments around the world and monitor the outbreak, it said.聽聽聽

The disease so far has affected at least 169 children, aged 1 month to 16 years, in 12 countries as of April 21 and they are mostly in the UK and other European countries. 鈥 Bloomberg