Artificial intelligence and the coming health revolution

WASHINGTON — Your next doctor could very well be a bot. And bots, or automated programs, are likely to play a key role in finding cures for some of the most difficult-to-treat diseases and conditions.

Artificial intelligence (AI) is rapidly moving into health care, led by some of the biggest technology companies and emerging start-ups using it to diagnose and respond to a raft of conditions.

Consider these examples:

• California researchers detected cardiac arrhythmia with 97% accuracy on wearers of an Apple Watch with the AI-based Cariogram application, opening up early treatment options to avert strokes.

• Scientists from Harvard and the University of Vermont developed a machine learning tool — a type of AI that enables computers to learn without being explicitly programmed — to better identify depression by studying Instagram posts, suggesting “new avenues for early screening and detection of mental illness.”

• Researchers from Britain’s University of Nottingham created an algorithm that predicted heart attacks better than doctors using conventional guidelines.

While technology has always played a role in medical care, a wave of investment from Silicon Valley and a flood of data from connected devices appear to be spurring innovation.

“I think a tipping point was when Apple released its Research Kit,” said Forrester Research analyst Kate McCarthy, referring to a program letting Apple users enable data from their daily activities to be used in medical studies.

McCarthy said advances in artificial intelligence has opened up new possibilities for “personalized medicine” adapted to individual genetics.

“We now have an environment where people can weave through clinical research at a speed you could never do before,” she said.

PREDICTIVE ANALYTICS
AI is better known in the tech field for uses such as autonomous driving, or defeating experts in the board game Go.

But it can also be used to glean new insights from existing data such as electronic health records and lab tests, says Narges Razavian, a professor at New York University’s (NYU’s) Langone School of Medicine who led a research project on predictive analytics for more than 100 medical conditions.

“Our work is looking at trends and trying to predict (disease) six months into the future, to be able to act before things get worse,” Razavian said.

• NYU researchers analyzed medical and lab records to accurately predict the onset of dozens of diseases and conditions including type 2 diabetes, heart or kidney failure, and stroke. The project developed software now used at NYU which may be deployed at other medical facilities.

• Google’s DeepMind division is using artificial intelligence to help doctors analyze tissue samples to determine the likelihood that breast and other cancers will spread, and develop the best radiotherapy treatments.

• Microsoft, Intel and other tech giants are also working with researchers to sort through data with AI to better understand and treat lung, breast, and other types of cancer.

• Google parent Alphabet’s life sciences unit Verily has joined Apple in releasing a smartwatch for studies including one to identify patterns in the progression of Parkinson’s disease. Amazon meanwhile offers medical advice through applications on its voice-activated artificial assistant Alexa.

IBM has been focusing on these issues with its Watson Health unit, which uses “cognitive computing” to help understand cancer and other diseases.

When IBM’s Watson computing system won the TV game show Jeopardy in 2011, “there were a lot of folks in health care who said that is the same process doctors use when they try to understand health care,” said Anil Jain, chief medical officer of Watson Health.

Systems like Watson, he said, “are able to connect all the disparate pieces of information” from medical journals and other sources “in a much more accelerated way.”

“Cognitive computing may not find a cure on day one, but it can help understand people’s behavior and habits” and their impact on disease, Jain said.

It’s not just major tech companies moving into health.

Research firm CB Insights this year identified 106 digital health start-ups applying machine learning and predictive analytics “to reduce drug discovery times, provide virtual assistance to patients, and diagnose ailments by processing medical images.”

Maryland-based start-up Insilico Medicine uses so-called “deep learning” to shorten drug testing and approval times, down from the current 10 to 15 years.

“We can take 10,000 compounds and narrow that down to 10 to find the most promising ones,” said Insilico’s Qingsong Zhu.

Insilico is working on drugs for amyotrophic lateral sclerosis (ALS), cancer, and age-related diseases, aiming to develop personalized treatments.

FINDING DEPRESSION
Artificial intelligence is also increasingly seen as a means for detecting depression and other mental illnesses, by spotting patterns that may not be obvious, even to professionals.

A research paper by Florida State University’s Jessica Ribeiro found it can predict with 80 to 90% accuracy whether someone will attempt suicide as far off as two years into the future.

Facebook uses AI as part of a test project to prevent suicides by analyzing social network posts.

And San Francisco’s Woebot Labs this month debuted on Facebook Messenger what it dubs the first chatbot offering “cognitive behavioral therapy” online — partly as a way to reach people wary of the social stigma of seeking mental health care.

New technologies are also offering hope for rare diseases.

Boston-based start-up FDNA uses facial recognition technology matched against a database associated with over 8,000 rare diseases and genetic disorders, sharing data and insights with medical centers in 129 countries via its Face2Gene application.

CAUTIOUS OPTIMISM
Lynda Chin, vice-chancellor and chief innovation officer at the University of Texas System, said she sees “a lot of excitement around these tools” but that technology alone is unlikely to translate into wide-scale health benefits.

One problem, Chin said, is that data from sources as disparate as medical records and Fitbits is difficult to access due to privacy and other regulations.

More important, she said, is integrating data in health care delivery where doctors may be unaware of what’s available or how to use new tools.

“Just having the analytics and data get you to step one,” said Chin. “It’s not just about putting an app on the app store.” — AFP